Born in Massachusetts, Conan Christopher O'Brien shifted to Los Angeles in search of opportunities. He started as a writer in HBO's Not Necessarily the News and later in The Wilton North Report until he was employed as a writer by Lorne Michaels in Saturday Night Live. He also wrote sketches for Tom Hanks and Jon Lovitz while a writer for the show. In 1991, O'Brien started writing and producing The Simpsons, which went on till 1993. He appeared on shows like DAG (2000), Andy Richter Controls the Universe (2003), How I Met Your Mother (2012), and Silicon Valley (2019), among so many others. Conan was the writer and producer of The Tonight Show with Conan O'Brien, which went on for two years from 2009 to 2010. He was the executive producer of Eagleheart (2011-2014), The Pete Holmes Show (2013-2014), and People of Earth (2016-2017). He is the creator, writer, and producer of the show Conan which began in 2010.

In the past, Conan O’Brien has worked with celebrity makeup artists which include: Erin Ayanian Monroe. Who is Conan O’Brien's hair stylist? Some of the hair stylists that Conan O’Brien has worked with for red carpet or editorial shoots include: Mara Schiavetti.